|
Inflammatory Bowel Diseases
|
0.130 |
GeneticVariation
|
group |
GWASCAT |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
Inflammatory Bowel Diseases
|
0.130 |
Biomarker
|
group |
BEFREE |
Intriguing examples such as GPR35 for inflammatory bowel disease and CXCR4 for viral infection are used as illustrations of how a systematic approach can aid in the prioritization of interesting drug discovery hypotheses.
|
30285606 |
2018 |
|
Inflammatory Bowel Diseases
|
0.130 |
GeneticVariation
|
group |
GWASDB |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
Inflammatory Bowel Diseases
|
0.130 |
GeneticVariation
|
group |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Inflammatory Bowel Diseases
|
0.130 |
Biomarker
|
group |
BEFREE |
The orphan receptor G protein-coupled receptor 35 (GPR35) has been associated with a range of diseases, including cancer, inflammatory bowel disease, diabetes, hypertension, and heart failure.
|
29860395 |
2018 |
|
Inflammatory Bowel Diseases
|
0.130 |
Biomarker
|
group |
BEFREE |
In this study, we investigated the contribution of GPR35-mediated signalling to mucosal repair of colonic epithelium in IBD.
|
28648739 |
2017 |
|
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
Hepatitis
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
|
Pleural effusion disorder
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
|
Encephalopathies
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
|
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Based on the apparent transformation activities of the two GPR35 clones in NIH3T3 cells, and the marked up-regulation of their expression levels in cancer tissues, it is speculated that these two novel isoforms of GPR35 are involved in the course of gastric cancer formation.
|
14965362 |
2004 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The orphan receptor G protein-coupled receptor 35 (GPR35) has been associated with a range of diseases, including cancer, inflammatory bowel disease, diabetes, hypertension, and heart failure.
|
29860395 |
2018 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The function of the CXCL17-CXCR8 (GPR35) biological axis in cancer has not been reported.
|
28943434 |
2017 |
|
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Based on the apparent transformation activities of the two GPR35 clones in NIH3T3 cells, and the marked up-regulation of their expression levels in cancer tissues, it is speculated that these two novel isoforms of GPR35 are involved in the course of gastric cancer formation.
|
14965362 |
2004 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
The orphan receptor G protein-coupled receptor 35 (GPR35) has been associated with a range of diseases, including cancer, inflammatory bowel disease, diabetes, hypertension, and heart failure.
|
29860395 |
2018 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
The function of the CXCL17-CXCR8 (GPR35) biological axis in cancer has not been reported.
|
28943434 |
2017 |
|
Cardiovascular Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
To assess the potential for GPR35 as a therapeutic target in cardiovascular disease, this study investigated the cardiovascular phenotype of a GPR35 knockout mouse under both basal conditions and following pathophysiological stimulation.
|
29860395 |
2018 |
|
Cardiovascular Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
GPR35, a family A orphan G protein-coupled receptor, has been implicated in inflammatory, neurological, and cardiovascular diseases.
|
28425521 |
2017 |
|
Diabetes Mellitus
|
0.020 |
Biomarker
|
group |
BEFREE |
GPR35 is a poorly characterized G protein-coupled receptor (GPCR) that has been suggested as a potential therapeutic target for the treatment of diabetes, hypertension and asthma.
|
21392828 |
2011 |
|
Diabetes Mellitus
|
0.020 |
AlteredExpression
|
group |
BEFREE |
As GPR35 is expressed in tissues such as the adipose tissue, immune cells and the gastrointestinal tract, this receptor could be a potential therapeutic target for the treatment of obesity, diabetes and other metabolic diseases.
|
30141532 |
2018 |
|
Hypertensive disease
|
0.020 |
Biomarker
|
group |
BEFREE |
This suggests that GPR35 is a potential novel drug target for therapeutic intervention in hypertension.
|
29860395 |
2018 |
|
Hypertensive disease
|
0.020 |
Biomarker
|
group |
BEFREE |
GPR35 is a poorly characterized G protein-coupled receptor (GPCR) that has been suggested as a potential therapeutic target for the treatment of diabetes, hypertension and asthma.
|
21392828 |
2011 |
|
Metabolic Diseases
|
0.020 |
AlteredExpression
|
group |
BEFREE |
As GPR35 is expressed in tissues such as the adipose tissue, immune cells and the gastrointestinal tract, this receptor could be a potential therapeutic target for the treatment of obesity, diabetes and other metabolic diseases.
|
30141532 |
2018 |
|
Metabolic Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
G protein-coupled receptor-35 (GPR35) has emerged as a potential target in the treatment of pain and inflammatory and metabolic diseases.
|
29795753 |
2018 |
|
Congenital Abnormality
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Single nucleotide polymorphisms of GPR35 have linked this receptor to coronary artery calcification, inflammatory bowel disease and primary sclerosing cholangitis, while chromosomal aberrations of the 2q37.3 locus and altered copy number of GPR35 have been linked with autism, Albight's hereditary osteodystrophy-like syndrome, and congenital malformations, respectively.
|
26232640 |
2017 |